5-Amino-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxylic acid → 5-amino-6-chloro-2-ethyl-N-{[1-(2-hydroxybutyl)piperidin-4-yl]methyl}-imidazo[1,2-a]pyridine-8-carboxamide

HRID 965809Notes

Reaction equation

HRID 965809 reaction equation
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([OH:15])=O)=[CH:4][C:3]=1[Cl:16].[NH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][N:22]([CH2:25][CH:26]([OH:29])[CH2:27][CH3:28])[CH2:21][CH2:20]1>>[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH2:11][CH3:12])[N:10]=[C:6]2[C:5]([C:13]([NH:17][CH2:18][CH:19]2[CH2:20][CH2:21][N:22]([CH2:25][CH:26]([OH:29])[CH2:27][CH3:28])[CH2:23][CH2:24]2)=[O:15])=[CH:4][C:3]=1[Cl:16]

Participants

3

Reactant 2

HCID 222364965-Amino-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxylic acidHCID 223132691-[4-(Aminomethyl)piperidin-1-yl]butan-2-ol

Product 1

HCID 103413815-amino-6-chloro-2-ethyl-N-{[1-(2-hydroxybutyl)piperidin-4-yl]methyl}-imidazo[1,2-a]pyridine-8-carboxamide

Procedure

The tilte compound (free base) was prepared according to the procedure described in the step 5 of Example 1 from 5-amino-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxilic acid (Example 4, Step 2) and 1-[4-(aminomethyl)piperidin-1-yl]butan-2-ol (Example 13, Step 2).

Workup

  1. customThe tilte compound (free base) was prepared

Sources & evidence

ORD record
ord-04980c413c5c432a81c7b1048389a21d
Source dataset
uspto-grants-2005_10
Patent number
US06951867B2

Reaction notes

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