Isobutylene oxide → 5-AMINO-6-CHLORO-N-{[1-(2-HYDROXY-2-METHYLPROPYL)PIPERIDIN-4-YL]METHYL}-2-METHYLIMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE

HRID 965812Notes

Reaction equation

HRID 965812 reaction equation
[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH3:11])[N:10]=[C:6]2[C:5]([C:12]([NH:14][CH2:15][CH:16]2[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]2)=[O:13])=[CH:4][C:3]=1[Cl:22].[CH3:23][C:24]1([CH3:27])[CH2:26][O:25]1>>[NH2:1][C:2]1[N:7]2[CH:8]=[C:9]([CH3:11])[N:10]=[C:6]2[C:5]([C:12]([NH:14][CH2:15][CH:16]2[CH2:21][CH2:20][N:19]([CH2:23][C:24]([OH:25])([CH3:27])[CH3:26])[CH2:18][CH2:17]2)=[O:13])=[CH:4][C:3]=1[Cl:22]

Participants

3

Reactant 2

HCID 11208Isobutylene oxideHCID 11174673HCID 11174673, compound

Product 1

HCID 100461205-AMINO-6-CHLORO-N-{[1-(2-HYDROXY-2-METHYLPROPYL)PIPERIDIN-4-YL]METHYL}-2-METHYLIMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE

Procedure

The title compound was prepared according to the procedure described in Example 14 from 5-amino-6-chloro-2-methyl-N-(piperidin-4-ylmethyl)imidazo[1,2-a]pyridine-8-carboxamide (Example 15, Step 2) and 2,2-dimethyloxirane.

Sources & evidence

ORD record
ord-543e7a8806244eaeb436419430142478
Source dataset
uspto-grants-2005_10
Patent number
US06951867B2

Reaction notes

Loading…