反应详情

A solution of 2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionic acid, methyl ester (intermediate 69-184 mg) and potassium hydroxide (131 mg) in MeOH (2.5 mL) was heated to reflux for 1 hour, then it was allowed to cool to r.t. and acidified to pH=3 with 10% hydrochloric acid solution and extracted with AcOEt (2×10 mL). The combined organic extracts were dried and concentrated in vacuo to a residue which was purified by flash chromatography (CH/AcOEt from 8:2 to 6:4) to give the title compound (141 mg) as a white solid.

1. temperatureto reflux for 1 hour
2. extractionextracted with AcOEt (2×10 mL)
3. customThe combined organic extracts were dried
4. concentrationconcentrated in vacuo to a residue which
5. customwas purified by flash chromatography (CH/AcOEt from 8:2 to 6:4)