反应详情

A suspension of N-(5-chloro-2-hydroxyphenyl)urea (53 mg, 0.28 mmol), cesium carbonate (92 mg, 0.28 mmol) and epibromohydrine (49 mg, 0.36 mmol) in dry DMF (0.6 mL) was stirred at room temperature for 24 hours. The mixture was then partitioned between ethyl acetate and water. The organic phase was washed with water three times, dried and concentrated to a solid residue. This crude product was recrystallized (ethyl ether and heptane to afford the subtitle compound (18 mg, 26.5%).

1. customThe mixture was then partitioned between ethyl acetate and water
2. washThe organic phase was washed with water three times
3. customdried
4. concentrationconcentrated to a solid residue
5. customThis crude product was recrystallized (ethyl ether and heptane