5-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide → 5-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide Hydrochloride

HRID 965988Notes

Reaction equation

HRID 965988 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[CH:20][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[N:22][CH:23]=3)[N:16]=[C:15]([C:28]([F:31])([F:30])[F:29])[CH:14]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[N:9]=[CH:10][S:11][CH:12]=1.[ClH:32].CO>>[ClH:32].[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[CH:20][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[N:22][CH:23]=3)[N:16]=[C:15]([C:28]([F:29])([F:30])[F:31])[CH:14]=2)[CH:5]=[CH:6][C:7]=1[C:8]1[N:9]=[CH:10][S:11][CH:12]=1

Participants

3

Reactant 2

HCID 178121385-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamideHCID 21893726Hydrochloride methanol

Product 1

HCID 223138485-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide HydrochlorideYield 64.1%

Procedure

5-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide (172 mg, 0.37 mmol) was dissolved with HCl-MeOH and the solvent was removed. The residue was washed with ethyl acetate to afford 120 mg (64.1%) of the titled compound as a slight yellow solid.

Workup

  1. customthe solvent was removed
  2. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-de296efdef83452eb027b05e5b84de64
Source dataset
uspto-grants-2005_10
Patent number
US06951876B2

Reaction notes

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