HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide → 5-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide | HCID 17812138 | — |
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Product | 5-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide Hydrochloride | HCID 22313848 | 64.1% |
Reaction Steps
5-(5-(3-Fluoro-4-(1,3-thiazol-4-yl)phenyl)-3-trifluoromethyl-1H-pyrazol-1-yl)-2-pyridinesulfonamide (172 mg, 0.37 mmol) was dissolved with HCl-MeOH and the solvent was removed. The residue was washed with ethyl acetate to afford 120 mg (64.1%) of the titled compound as a slight yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06951876B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-de296efdef83452eb027b05e5b84de64 |
| Source note | uspto-grants-2005_10 |