2-Acetylbutyrolactone → HCID 178432037, compound

HRID 965992Notes

Reaction equation

HRID 965992 reaction equation
Br.[NH2:2][C:3]1[NH:7][N:6]=[C:5]([CH3:8])[C:4]=1[Br:9].[C:10]([CH:13]1[CH2:18][CH2:17][O:16][C:14]1=[O:15])(=O)[CH3:11]>C(O)C>[Br:9][C:4]1[C:5]([CH3:8])=[N:6][N:7]2[C:14]([OH:15])=[C:13]([CH2:18][CH2:17][OH:16])[C:10]([CH3:11])=[N:2][C:3]=12

Participants

4

Reactant 2

HCID 106012-AcetylbutyrolactoneHCID 178419529HCID 178419529, compound

Product 1

HCID 178432037HCID 178432037, compoundYield 31.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-amino-4-bromo-3-methylpyrazole hydrobromide (13 g, 51 mmol) and α-acetyl-γ-butyrolactone (6.8 g, 53 mmol) in ethanol (65 mL) was heated under reflux for nine hours. After cooling to room temperature, the resulting crystals were collected by filtration, to give the title compound (4.6 g) as white crystals.

Workup

  1. temperatureunder reflux for nine hours
  2. filtrationthe resulting crystals were collected by filtration

Sources & evidence

ORD record
ord-301fb18165de450c9d1f7329c9ad1eec
Source dataset
uspto-grants-2005_10
Patent number
US06951865B2

Reaction notes

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