HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 178422303, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-Acetylbutyrolactone | HCID 10601 | — |
| Reactant | 1H-Pyrazol-3-amine, 5-methyl- | HCID 93146 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178422303 | HCID 178422303 | 85,788% |
Reaction Steps
A solution of 3-amino-5-methylpyrazole (25.0 g, 0.26 mole), α-acetyl-γ-butyrolactone (34.5 g, 0.27 mmol) and acetic acid (5 mL) in toluene (350 mL) was heated under reflux for three hours. After cooling to room temperature, the resulting crystals were collected by filtration and washed with ethyl acetate, to give the title compound (48.0 g) as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06951865B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-9a738e0699544fa89bdd9d951bc1e72a |
| Source note | uspto-grants-2005_10 |