Acetic Acid → HCID 178422303, compound

HRID 965994Notes

Reaction equation

HRID 965994 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.[C:8]([CH:11]1[CH2:16][CH2:15][O:14][C:12]1=[O:13])(=O)[CH3:9].C(O)(=O)C>C1(C)C=CC=CC=1>[OH:14][CH2:15][CH2:16][C:11]1[C:8]([CH3:9])=[N:1][C:2]2[N:3]([N:4]=[C:5]([CH3:7])[CH:6]=2)[C:12]=1[OH:13]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 106012-AcetylbutyrolactoneHCID 931461H-Pyrazol-3-amine, 5-methyl-

Product 1

HCID 178422303HCID 178422303, compoundYield 85,788%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 3-amino-5-methylpyrazole (25.0 g, 0.26 mole), α-acetyl-γ-butyrolactone (34.5 g, 0.27 mmol) and acetic acid (5 mL) in toluene (350 mL) was heated under reflux for three hours. After cooling to room temperature, the resulting crystals were collected by filtration and washed with ethyl acetate, to give the title compound (48.0 g) as white crystals.

Workup

  1. temperatureunder reflux for three hours
  2. filtrationthe resulting crystals were collected by filtration
  3. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-9a738e0699544fa89bdd9d951bc1e72a
Source dataset
uspto-grants-2005_10
Patent number
US06951865B2

Reaction notes

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