反应详情

Formononetine (90 g; 335 mmol) was suspended in acetonitrile, K2CO3 was added and the mixture was stirred for about 20 minutes at r.t. Pivaloyl chloride (59.85 g; 496 mmol) was dropped into the mixture, then the reaction was stirred for further 15 minutes and quenched into water. The solid was filtered, washed with water, dissolved in CHCl3; the solution was dried and evaporated to dryness to obtain the title compound, which can be crystallised from hot toluene. 102 g of a white crystalline powder were obtained.

1. stirringthe reaction was stirred for further 15 minutes
2. customquenched into water
3. filtrationThe solid was filtered
4. washwashed with water
5. dissolutiondissolved in CHCl3
6. customthe solution was dried
7. customevaporated to dryness