HCID 22314545, compound → 1-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone

HRID 966095Notes

Reaction equation

HRID 966095 reaction equation
[CH3:1][C:2]([NH:6][CH2:7][C:8]([C:10]1[CH:30]=[CH:29][C:13]2[O:14]C(C3C=CC=CC=3)(C3C=CC=CC=3)[O:16][C:12]=2[C:11]=1[O:31][CH3:32])=[O:9])([CH3:5])[CH2:3][CH3:4]>Cl>[OH:16][C:12]1[C:11]([O:31][CH3:32])=[C:10]([C:8](=[O:9])[CH2:7][NH:6][C:2]([CH3:1])([CH3:5])[CH2:3][CH3:4])[CH:30]=[CH:29][C:13]=1[OH:14]

Participants

3

Reactant 1

HCID 22314545HCID 22314545, compound

Product 1

HCID 223145401-(3,4-Dihydroxy-2-methoxyphenyl)-2-(1,1-dimethylpropylamino)ethanone

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

25 g of 2-(1,1-dimethylpropylamino)-1-(4-methoxy-2,2-diphenylbenzo[1,3]dioxol-5-yl) ethanone is refluxed with 50 mL of 15% methanolic hydrochloric acid for 2 hours with stirring. The solvent is distilled off under reduced pressure and the residue is dissolved in acetonitrile and combined with ethyl acetate. The precipitated crystals are suction filtered and washed with acetonitrile and diethyl ether. Yield: 15 g (92%) of the compound as the hydrochloride.

Workup

  1. distillationThe solvent is distilled off under reduced pressure
  2. dissolutionthe residue is dissolved in acetonitrile
  3. filtrationfiltered
  4. washwashed with acetonitrile and diethyl ether

Sources & evidence

ORD record
ord-1d0a380a21a44297a99d2ed5dcfd711a
Source dataset
uspto-grants-2005_10
Patent number
US06951888B2

Reaction notes

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