反应详情

173 g (2,4,6-trimethylphenyl)acetic acid is refluxed in 131 mL of concentrated hydrochloric acid and 1.1 L of methanol for 3 hours with stirring. The solvent is distilled off under reduced pressure and the aqueous phase extracted twice with diethyl ether. The combined organic phases are extracted twice with a saturated aqueous sodium hydrogen carbonate solution and dried with sodium sulfate and the solvent is distilled off under reduced pressure. The residue is fractionally distilled. Yield: 116 g (57%); bp15: 140° C.

1. distillationThe solvent is distilled off under reduced pressure
2. extractionthe aqueous phase extracted twice with diethyl ether
3. extractionThe combined organic phases are extracted twice with a saturated aqueous sodium hydrogen carbonate solution
4. dry with materialdried with sodium sulfate
5. distillationthe solvent is distilled off under reduced pressure
6. distillationThe residue is fractionally distilled
7. custom140° C.