Dihydrolipoic Acid → 6,8-Bisacetylmercaptooctanoic acetic anhydride
반응식
[C:1]([S:4][CH:5]([CH2:13][CH2:14][S:15][C:16](=[O:18])[CH3:17])[CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])(=[O:3])[CH3:2].C1[C@@H](CCC[CH2:27][C:28](O)=[O:29])SSC1.SC(CCS)CCCCC(O)=O>>[C:28]([O:11][C:10](=[O:12])[CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([S:4][C:1](=[O:3])[CH3:2])[CH2:13][CH2:14][S:15][C:16](=[O:18])[CH3:17])(=[O:29])[CH3:27]참가 물질
4
실험 절차
6,8-bisacetylmercaptooctanoic (henceforth referred to as bis-acetyl lipoic acid) was prepared from commercially available—lipoic acid using a three step procedure. These steps were as follows: Lipoic acid was first reduced to 6,8-bismercaptooctanoic acid which was then acetylated to produce 6,8-bisacetylmercaptooctanoic acetic anhydride. This 6,8-bisacetylmercaptooctanoic acetic anhydride was then selectively hydrolyzed to produce the 6,8-bisacetylmercaptooctanoic acid.
출처 및 근거
- ORD 기록
- ord-1fabf57c047948248d9ffb312df86c8d
- 출처 데이터셋
- uspto-grants-2005_10
- 특허 번호
- US06951887B2
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