HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dihydrolipoic Acid → 6,8-Bisacetylmercaptooctanoic acetic anhydride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dihydrolipoic Acid | HCID 421 | — |
| Reactant | Lipoic acid | HCID 6112 | — |
| Reactant | 6,8-Bis(acetylthio)octanoic acid | HCID 9926084 | — |
| Product | 6,8-Bisacetylmercaptooctanoic acetic anhydride | HCID 86585610 | — |
Reaction Steps
6,8-bisacetylmercaptooctanoic (henceforth referred to as bis-acetyl lipoic acid) was prepared from commercially available—lipoic acid using a three step procedure. These steps were as follows: Lipoic acid was first reduced to 6,8-bismercaptooctanoic acid which was then acetylated to produce 6,8-bisacetylmercaptooctanoic acetic anhydride. This 6,8-bisacetylmercaptooctanoic acetic anhydride was then selectively hydrolyzed to produce the 6,8-bisacetylmercaptooctanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06951887B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-1fabf57c047948248d9ffb312df86c8d |
| Source note | uspto-grants-2005_10 |