Propargylamine → HCID 22314124, compound

HRID 966179Notes

Reaction equation

HRID 966179 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([O:17][CH2:18][CH2:19][CH2:20]Br)=[CH:16][C:11]=3[S:10][N:9]=2)=[CH:4][CH:3]=1.[CH2:22]([NH2:25])[C:23]#[CH:24]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:12]3[CH:13]=[CH:14][C:15]([O:17][CH2:18][CH2:19][CH2:20][NH:25][CH2:22][C:23]#[CH:24])=[CH:16][C:11]=3[S:10][N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 239041PropargylamineHCID 223140693-(4-Bromo-phenyl)-6-(3-bromo-propoxy)-benzo[d]isothiazole

Product 1

HCID 22314124HCID 22314124, compound

Procedure

In analogy to example 3.1, 3-(4-Bromo-phenyl)-6-(3-bromo-propoxy)-benzo[d]isothiazole and Prop-2-ynylamine were converted to yield {3-[3-(4-Bromo-phenyl)-benzo[d]isothiazol-6-yloxy]-propyl}-prop-2-ynyl-amine as off-white semisolid, MS: 40 1 (MH+, 1Br).

Sources & evidence

ORD record
ord-e2a02dd574ff463fbfa56f34303e19fd
Source dataset
uspto-grants-2005_10
Patent number
US06951879B2

Reaction notes

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