Acetone → HCID 22314812, compound

HRID 966415Notes

Reaction equation

HRID 966415 reaction equation
CC(C)=O.[CH2:5]([N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.O[C:19]([CH3:23])([CH3:22])[C:20]#[N:21]>CN(C)C(=O)C>[CH2:5]([N:12]1[CH2:17][CH2:16][N:15]([C:19]([CH3:23])([CH3:22])[C:20]#[N:21])[CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 6406Acetone CyanohydrinHCID 759941-Benzylpiperazine

Product 1

HCID 22314812HCID 22314812, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
45 °C

Procedure

4.5 ml of acetone, 20 g of dry MGSO4, 10 g of N,N-dimethylacetamide, 10 g of 1-benzylpiperazine and 9.5 ml of 2-hydroxyisobutyronitrile are mixed together and heated at 45° C. for 48 hours with vigorous stirring. The reaction mixture is poured onto ice and left stirring for 30 minutes. The mixture is extracted with ether, the organic phase is washed several times with water and dried over Na2SO4, and the solvent is evaporated off under vacuum. 13 g of the expected product are obtained.

Workup

  1. additionThe reaction mixture is poured onto ice
  2. waitleft
  3. extractionThe mixture is extracted with ether
  4. washthe organic phase is washed several times with water
  5. dry with materialdried over Na2SO4
  6. customthe solvent is evaporated off under vacuum

Sources & evidence

ORD record
ord-bdb90b6a1e1243f28bbf10a48066509a
Source dataset
uspto-grants-2005_10
Patent number
US06951940B2

Reaction notes

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