反应详情

Crude, unpurified compound 8 (5 g) is added portionwise to a 0° C. commercially available solution of hydrogen chloride in 1,4-dioxan (Aldrich, 4 M, 35 ml.) Compound 8a slowly dissolves to afford a clear yellow solution. After stirring for approximately 12 hours, the reaction mixture turns cloudy. TLC on silica using methylene chloride:ethyl acetate (9:1) as the eluent shows the starting material has been consumed. The reaction mixture is filtered and a white solid is obtained. The solid is washed exhaustively with ether (50 mL) to afford 266 mg of compound 9.

1. dissolutionslowly dissolves
2. customto afford a clear yellow solution
3. customhas been consumed
4. filtrationThe reaction mixture is filtered
5. customa white solid is obtained
6. washThe solid is washed exhaustively with ether (50 mL)