Formamide → HCID 12994442, compound

HRID 966428Notes

Reaction equation

HRID 966428 reaction equation
Cl.[NH2:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][C:12]2[CH:13]=[C:14]([C:18]([NH:20][C:21]3[CH:22]=[C:23]([C:27]([NH:29][CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])[N:24]([CH3:26])[CH:25]=3)=[O:19])[N:15]([CH3:17])[CH:16]=2)=[O:10])[N:6]([CH3:8])[CH:7]=1.[CH:35](N)=[O:36].C(OCC)=O>O>[CH:35]([NH:2][C:3]1[CH:4]=[C:5]([C:9]([NH:11][C:12]2[CH:13]=[C:14]([C:18]([NH:20][C:21]3[CH:22]=[C:23]([C:27]([NH:29][CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])[N:24]([CH3:26])[CH:25]=3)=[O:19])[N:15]([CH3:17])[CH:16]=2)=[O:10])[N:6]([CH3:8])[CH:7]=1)=[O:36]

Participants

5

Reactant 3

HCID 713FormamideHCID 8025Ethyl formateHCID 22315697HCID 22315697, compound

Product 1

HCID 12994442HCID 12994442, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of the compound obtained in example 1 (4 g), formamide (12 ml) and ethyl formate (12 ml) was stirred at 90° C. for 5 hours. The organic solvent was allowed under vacuum, the brown residue treated with water (100 ml) and the suspension stirred for one hour. The suspension was filtered and the solid washed with cold water (20 ml) yielding, after desiccation under vacuum at 40° C., the title compound (6.8 g; y=90%) as a brown powder.

Workup

  1. filtrationThe suspension was filtered
  2. washthe solid washed with cold water (20 ml)
  3. customyielding
  4. customat 40° C.

Sources & evidence

ORD record
ord-361ab1a0afd44504a9b9a6cc95697cbc
Source dataset
uspto-grants-2005_10
Patent number
US06951951B2

Reaction notes

Loading…