Imidazole → 4-((Tert-butyldimethylsilyl)oxy)butan-1-amine

HRID 966942Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6].[Si:7](Cl)([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8].N1C=CN=C1>>[Si:7]([O:6][CH2:5][CH2:4][CH2:3][CH2:2][NH2:1])([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:9])[CH3:8]

Participants

Reactant 3

HCID 795Imidazole

HCID 258684-Amino-1-butanol

HCID 28928tert-Butyldimethylsilyl chloride

Product 1

HCID 107506864-((Tert-butyldimethylsilyl)oxy)butan-1-amine

Procedure

In a manner similar to that in Reference Example 1, 4-amino-1-butanol was reacted with tert-butyldimethylsilyl chloride in the presence of imidazole to give 4-(tert-butyldimethylsilyloxy)-1-butylamine.

Sources & evidence

ORD record: ord-c7e68210966941f7972aff00b68a638f
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953785B2

Reaction notes

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