Hydrochloric Acid → HCID 131723436, compound

HRID 966996Notes

Reaction equation

C(OC(=O)[NH:7][C:8]([C:11](=[O:45])[NH:12][C@H:13]([CH2:36][O:37][CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[C:14]([N:16]1[CH2:21][CH2:20][N:19]2[C:22](=[O:26])[N:23]([CH3:25])[CH2:24][C@:18]2([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][C:29]=2[F:35])[CH2:17]1)=[O:15])([CH3:10])[CH3:9])(C)(C)C.[ClH:47]>CCO>[ClH:47].[NH2:7][C:8]([CH3:10])([CH3:9])[C:11]([NH:12][C@H:13]([CH2:36][O:37][CH2:38][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1)[C:14]([N:16]1[CH2:21][CH2:20][N:19]2[C:22](=[O:26])[N:23]([CH3:25])[CH2:24][C@:18]2([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([F:34])=[CH:30][C:29]=2[F:35])[CH2:17]1)=[O:15])=[O:45]

Participants

Conditions

Temperature: 0 °C

Procedure

To a solution of the compound of Example 198, Step D (12 mg) in EtOH (2 mL, 0° C.) was added conc. HCl (0.2 mL). The solution was stirred at 0° C. for 1 h and concentrated down to deliver 10 mg of Example 198, Step E: +APcI MS (M+1)+ 544; 1H NMR=400 MHz (CD3OD) δ: 7.31 (br m, 6H), 6.83 (m, 2H), 2.59 (br s, 3H), 1.56 (br s, 6H).

Workup

concentrationconcentrated down

Sources & evidence

ORD record: ord-5672a7e7673640768da914edffb1c8d2
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953791B2

Reaction notes

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