2-(4-Fluorophenoxy)nicotinic acid → 4'-[[[2-[4-Fluorophenoxy]-pyridine-3-carbonyl]-amino]-methyl]-biphenyl-3-carboxylic acid methyl ester

HRID 967118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 967118
[F:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][C:7]2[N:15]=[CH:14][CH:13]=[CH:12][C:8]=2[C:9]([OH:11])=O)=[CH:4][CH:3]=1.[CH3:18][O:19][C:20]([C:22]1[CH:23]=[C:24]([C:28]2[CH:33]=[CH:32][C:31]([CH2:34][NH2:35])=[CH:30][CH:29]=2)[CH:25]=[CH:26][CH:27]=1)=[O:21].O.ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC>CN(C)C=O.O>[CH3:18][O:19][C:20]([C:22]1[CH:23]=[C:24]([C:28]2[CH:33]=[CH:32][C:31]([CH2:34][NH:35][C:9]([C:8]3[C:7]([O:6][C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:17][CH:16]=4)=[N:15][CH:14]=[CH:13][CH:12]=3)=[O:11])=[CH:30][CH:29]=2)[CH:25]=[CH:26][CH:27]=1)=[O:21]

Komponenten

7

Edukt 4

HCID 6051232-(4-Fluorophenoxy)nicotinic acidHCID 1394186Methyl 3-[4-(aminomethyl)phenyl]benzoateHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrate

Produkt 1

HCID 206014024'-[[[2-[4-Fluorophenoxy]-pyridine-3-carbonyl]-amino]-methyl]-biphenyl-3-carboxylic acid methyl esterAusbeute 54,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a stirred solution of 290 mg (1.24 mmol.) 2-[4-fluoro-phenoxy]-nicotinic acid, 300 mg (1.24 mmol.) 4′-aminomethyl-biphenyl-3-carboxylic acid methyl ester and 184 mg (1.36 mmol.) 1-hydroxybenzotriazole hydrate in 10 mL dimethylformamide at ambient temperature was added 285 mg (1.49 mmol.) 1-[3-[dimethylamino]propyl]-3-ethylcarbodiimide hydrochloride. The mixture was stirred at ambient temperature for 18 hours then poured into water and extracted with ethyl acetate. The ethyl acetate extracts were combined, washed successively with 1N NaOH, water, brine then dried (MgSO4 ) and concentrated in vacuo to give an oil. Chromatography on silica Gel eluting with ethyl acetate/hexanes (1:1) gave 310 mg 4′-[[[2-[4-Fluorophenoxy]-pyridine-3-carbonyl]-amino]-methyl]-biphenyl-3-carboxylic acid methyl ester as an oil.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washwashed successively with 1N NaOH, water, brine
  3. dry with materialthen dried (MgSO4 )
  4. concentrationconcentrated in vacuo
  5. customto give an oil

Quellen und Nachweise

ORD-Eintrag
ord-09ddac9f7929458e9ffe26f2495cffd0
Quelldatensatz
uspto-grants-2005_10
Patentnummer
US06953810B2

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