Hydrochloric Acid → HCID 178484013, compound

HRID 967130Notes

Reaction equation

HRID 967130 reaction equation
[C:1]([O:5][C:6](=[O:21])[N:7]([CH2:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][OH:20])[CH2:12][CH2:11]1)[CH3:8])([CH3:4])([CH3:3])C.Cl.ClC(OC1C=[CH:31][C:30]([Cl:33])=[CH:29]C=1)=O>CO.O>[Cl:33][C:30]1[CH:31]=[CH:3][C:1]([O:5][C:6](=[O:21])[N:7]([CH2:9][C@H:10]2[CH2:11][CH2:12][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][OH:20])[CH2:14][CH2:15]2)[CH3:8])=[CH:4][CH:29]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1390594-Chlorophenyl chloroformateHCID 178484014HCID 178484014, compound

Product 1

HCID 178484013HCID 178484013, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

In analogy to the reactions described in examples 1.5 and 1.7 trans-[4-(4-hydroxy-butyl)-cyclohexylmethyl]-methyl-carbamic acid tert-butyl ester (example 3.2) was treated with hydrogen chloride solution in methanol/water followed by acylation with 4-chlorophenyl chloroformate giving trans-[4-(4-hydroxy-butyl)-cyclohexylmethyl]-methyl-carbamic acid 4-chloro-phenyl ester as colorless viscous oil, MS: 354 (MH+, 1Cl).

Sources & evidence

ORD record
ord-00e19cefc85240958b0be3cf16112e59
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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