反应详情

0.62 g (2.03 mmol) trans-[4-(2-hydroxy-ethyl)-cyclohexylmethyl]-methyl-carbamic acid benzyl ester dissolved in 10 ml of tetrahydrofuran were submitted to a hydrogenation over 0.3 g of 5% palladium on charcoal as catalyst, at normal pressure and ambient temperature. The cleavage of the benzyloxycarbonyl group was complete after 3 hours. After removal of the catalyst by filtration and evaporation of the solvent, 0.33 g (95%) of trans-2-(4-methylaminomethyl-cyclohexyl)-ethanol were obtained as a colorless oil, MS: 172 (MH+).

1. customAfter removal of the catalyst
2. filtrationby filtration and evaporation of the solvent