Hydrochloric Acid → HCID 178483633, compound

HRID 967158Notes

Reaction equation

HRID 967158 reaction equation
[ClH:1].C(O[C:7]([N:9](C)[CH2:10][CH2:11][C@H:12]1[CH2:17][CH2:16][C@H:15]([CH2:18][CH2:19][CH2:20][O:21][S:22]([CH3:25])(=[O:24])=[O:23])[CH2:14][CH2:13]1)=O)(C)(C)C>O1CCOCC1.CCOCC>[ClH:1].[CH3:7][NH:9][CH2:10][CH2:11][C@H:12]1[CH2:17][CH2:16][C@H:15]([CH2:18][CH2:19][CH2:20][O:21][S:22]([CH3:25])(=[O:24])=[O:23])[CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178483636HCID 178483636, compound

Product 1

HCID 178483633HCID 178483633, compoundYield 92.4%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

30 ml of 4N hydrogen chloride solution in dioxan was added to 4.06 g (10.8 mmol) of trans methanesulfonic acid 3-{4-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-cyclohexyl}-propyl ester. After stirring of the reaction mixture for 3 hours at room temperature, it was concentrated under reduced pressure. The residue formed was stirred in ether and the crystals formed were filtered off and washed with ether. After drying under reduced pressure and at and 45° C., 3.12 g (92.4%) trans-methanesulfonic acid 3-[4-(2-methylamino-ethyl)-cyclohexyl]-propyl ester HCl salt could be isolated as colorless crystals, MS: 278 (MH+).

Workup

  1. concentrationit was concentrated under reduced pressure
  2. customThe residue formed
  3. customthe crystals formed
  4. filtrationwere filtered off
  5. washwashed with ether
  6. customAfter drying under reduced pressure

Sources & evidence

ORD record
ord-64108e904fbc40e6ac7fd118aec2a02b
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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