反应详情

30 ml of 4N hydrogen chloride solution in dioxan was added to 4.06 g (10.8 mmol) of trans methanesulfonic acid 3-{4-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-cyclohexyl}-propyl ester. After stirring of the reaction mixture for 3 hours at room temperature, it was concentrated under reduced pressure. The residue formed was stirred in ether and the crystals formed were filtered off and washed with ether. After drying under reduced pressure and at and 45° C., 3.12 g (92.4%) trans-methanesulfonic acid 3-[4-(2-methylamino-ethyl)-cyclohexyl]-propyl ester HCl salt could be isolated as colorless crystals, MS: 278 (MH+).

1. concentrationit was concentrated under reduced pressure
2. customThe residue formed
3. customthe crystals formed
4. filtrationwere filtered off
5. washwashed with ether
6. customAfter drying under reduced pressure