Hydrochloric Acid → HCID 178483629, compound

HRID 967173Notes

Reaction equation

HRID 967173 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][C@H:11]1[CH2:16][CH2:15][C@H:14](/[CH:17]=[CH:18]/[CH2:19][OH:20])[CH2:13][CH2:12]1)C)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[CH3:6][NH:7][CH2:9][CH2:10][C@H:11]1[CH2:16][CH2:15][C@H:14](/[CH:17]=[CH:18]/[CH2:19][OH:20])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178483631HCID 178483631, compound

Product 1

HCID 178483629HCID 178483629, compoundYield 98.6%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 200 mg (0.672 mmol) trans{2-[4-(3-hydroxy-(E)-propenyl)-cyclohexyl]-ethyl}-methyl-carbamic acid tert-butyl ester in 2 ml 4M hydrogen chloride solution in dioxane was stirred for 30 minutes at room temperature. The reaction mixture was then concentrated under reduced pressure. The crude HCl-salt was triturated two times with dry ether and the crystalline product then dried for several hours at 45° C. and 15 mbar to give 155 mg (98.6%) of pure trans-3-[4-(2-methylamino-ethyl)-cyclohexyl]-(E)-prop-2-en-1-ol HCl-salt as colorless cristalls, MS: 198 (MH+).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customThe crude HCl-salt was triturated two times with dry ether
  3. customthe crystalline product then dried for several hours at 45° C.

Sources & evidence

ORD record
ord-b744bf288de94b53ab37e92f9d83c0de
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

Loading…