反应详情

A solution of 200 mg (0.672 mmol) trans{2-[4-(3-hydroxy-(E)-propenyl)-cyclohexyl]-ethyl}-methyl-carbamic acid tert-butyl ester in 2 ml 4M hydrogen chloride solution in dioxane was stirred for 30 minutes at room temperature. The reaction mixture was then concentrated under reduced pressure. The crude HCl-salt was triturated two times with dry ether and the crystalline product then dried for several hours at 45° C. and 15 mbar to give 155 mg (98.6%) of pure trans-3-[4-(2-methylamino-ethyl)-cyclohexyl]-(E)-prop-2-en-1-ol HCl-salt as colorless cristalls, MS: 198 (MH+).

1. concentrationThe reaction mixture was then concentrated under reduced pressure
2. customThe crude HCl-salt was triturated two times with dry ether
3. customthe crystalline product then dried for several hours at 45° C.