2-(Ethylamino)ethanol → HCID 178464087, compound

HRID 967191Notes

Reaction equation

HRID 967191 reaction equation
Br[CH2:2]/[CH:3]=[CH:4]/[CH2:5][O:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]([CH3:29])[S:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:10][CH2:9]1.[CH2:30]([NH:32][CH2:33][CH2:34][OH:35])[CH3:31]>CN(C)C(=O)C>[CH2:30]([N:32]([CH2:33][CH2:34][OH:35])[CH2:2]/[CH:3]=[CH:4]/[CH2:5][O:6][CH2:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]([CH3:29])[S:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:10][CH2:9]1)[CH3:31]

Participants

4

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 178484053HCID 178484053, compound

Product 1

HCID 178464087HCID 178464087, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In analogy to the method described in example 12.1, trans-N-[4-(4-bromo-(E)-but-2-enyloxymethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide was reacted with ethyl-(2-hydroxy-ethyl)-amine in N,N-dimethylacetamide at room temperature to yield trans-N-(4-{4-[ethyl-(2-hydroxy-ethyl)-amino]-(E)-but-2-enyloxymethyl}-cyclohexylmethyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide as light yellow solid, MS: 507 (MH+).

Sources & evidence

ORD record
ord-41b62439445c4beda84de9c4004a4d31
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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