反应详情

A solution of 12.5 g (corresponds to 28.9 mmol) of crude trans-methanesulfonic acid 3-{4-[(tert-butoxycarbonyl-methyl-amino)-methyl]-cyclohexyl}-prop-2-ynyl ester in 160 ml methylenechloride was treated at 0° C. with 78 ml of trifluoroacetic acid (for 30 minutes). After 15 minutes at this temperature, the reaction was evaporated, redissolved in toluene and evaporated (4×) to give 23.12 g of crude trans-methanesulfonic acid 3-(4-methylaminomethyl-cyclohexyl)-prop-2-ynyl ester trifluoro-acetate as dark brown viscous oil, MS: 260 (MH+).

1. customthe reaction was evaporated
2. dissolutionredissolved in toluene
3. customevaporated (4×)