HRID967312

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7940

Glutaric anhydride

C5H6O3

结构：CCOc1ccc(C2=NN(C3CCN(S(=O)(=O)c4ccc(C)cc4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OCC

HCID10175016

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(C2=NN(C3CCN(C(=O)CCCC(=O)O)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OCC

HCID10196063

未命名化合物

PROCEDURE

实验过程

Prepared from glutaric anhydride and starting compound A2 as described for compound 1. After evaporating the pyridine, the residue is partitioned between ethyl acetate and 1N hydrochloric acid. The ethyl acetate solution is dried over magnesium sulfate and evaporated. Crystallisation from diethyl ether. M. p. 133-135° C.

WORKUP

后处理

customAfter evaporating the pyridine
customthe residue is partitioned between ethyl acetate and 1N hydrochloric acid
dry with materialThe ethyl acetate solution is dried over magnesium sulfate
customevaporated
customCrystallisation from diethyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aa14bee00c2d41e4aef49e9d938faaad
来源数据集: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06953853B2
来源说明: uspto-grants-2005_10

反应 SMILES

[C:1]1(=[O:8])[O:7][C:5](=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH2:9]([O:11][C:12]1[CH:13]=[C:14]([C:21]2[C@@H:30]3[C@@H:25]([CH2:26][CH:27]=[CH:28][CH2:29]3)[C:24](=[O:31])[N:23]([CH:32]3[CH2:37][CH2:36][N:35](S(C4C=CC(C)=CC=4)(=O)=O)[CH2:34][CH2:33]3)[N:22]=2)[CH:15]=[CH:16][C:17]=1[O:18][CH2:19][CH3:20])[CH3:10]>>[CH2:9]([O:11][C:12]1[CH:13]=[C:14]([C:21]2[C@@H:30]3[C@@H:25]([CH2:26][CH:27]=[CH:28][CH2:29]3)[C:24](=[O:31])[N:23]([CH:32]3[CH2:33][CH2:34][N:35]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][C:1]([OH:7])=[O:8])[CH2:36][CH2:37]3)[N:22]=2)[CH:15]=[CH:16][C:17]=1[O:18][CH2:19][CH3:20])[CH3:10]