HCID 10128150, compound → HCID 86601097, compound

HRID 967320Notes

Reaction equation

HRID 967320 reaction equation
[Cl:1][CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9](=[O:13])[O:10]2)=[CH:5][CH:4]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:24]2[C@@H:33]3[C@@H:28]([CH2:29][CH:30]=[CH:31][CH2:32]3)[C:27](=[O:34])[N:26]([CH:35]3[CH2:40][CH2:39][N:38](C4C=CC([N+]([O-])=O)=CC=4)[CH2:37][CH2:36]3)[N:25]=2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]>O>[ClH:1].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:24]2[C@@H:33]3[C@@H:28]([CH2:29][CH:30]=[CH:31][CH2:32]3)[C:27](=[O:34])[N:26]([CH:35]3[CH2:40][CH2:39][N:38]([CH2:2][C:3]4[CH:12]=[C:11]5[C:6]([CH:7]=[CH:8][C:9](=[O:13])[O:10]5)=[CH:5][CH:4]=4)[CH2:37][CH2:36]3)[N:25]=2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

Participants

4

Reactant 2

HCID 10128150HCID 10128150, compoundHCID 22311322HCID 22311322, compound

Product 1

HCID 86601097HCID 86601097, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 7-Chloromethyl-chromen-2-one and starting compound A1 as described for compound 11. After the addition of water, the mixture is extracted with diethyl ether. The ether solution is dried over magnesium sulfate. After the addition of a saturated solution of hydrochloric acid in ether, the compound precipitates. M. p. 264-267° C.

Workup

  1. extractionthe mixture is extracted with diethyl ether
  2. dry with materialThe ether solution is dried over magnesium sulfate
  3. additionAfter the addition of a saturated solution of hydrochloric acid in ether
  4. customthe compound precipitates

Sources & evidence

ORD record
ord-67b317b5dbb243cfaa1e15855ec3c082
Source dataset
uspto-grants-2005_10
Patent number
US06953853B2

Reaction notes

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