HRID967320

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C2=NN(C3CCN(c4ccc([N+](=O)[O-])cc4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC

HCID10128150

未命名化合物

HCID22311322

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C2=NN(C3CCN(Cc4ccc5ccc(=O)oc5c4)CC3)C(=O)[C@@H]3CC=CC[C@H]23)cc1OC.Cl

HCID86601097

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Prepared from 7-Chloromethyl-chromen-2-one and starting compound A1 as described for compound 11. After the addition of water, the mixture is extracted with diethyl ether. The ether solution is dried over magnesium sulfate. After the addition of a saturated solution of hydrochloric acid in ether, the compound precipitates. M. p. 264-267° C.

WORKUP

后处理

extractionthe mixture is extracted with diethyl ether
dry with materialThe ether solution is dried over magnesium sulfate
additionAfter the addition of a saturated solution of hydrochloric acid in ether
customthe compound precipitates

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-67b317b5dbb243cfaa1e15855ec3c082
来源数据集: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06953853B2
来源说明: uspto-grants-2005_10

反应 SMILES

[Cl:1][CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9](=[O:13])[O:10]2)=[CH:5][CH:4]=1.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:24]2[C@@H:33]3[C@@H:28]([CH2:29][CH:30]=[CH:31][CH2:32]3)[C:27](=[O:34])[N:26]([CH:35]3[CH2:40][CH2:39][N:38](C4C=CC([N+]([O-])=O)=CC=4)[CH2:37][CH2:36]3)[N:25]=2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]>O>[ClH:1].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:24]2[C@@H:33]3[C@@H:28]([CH2:29][CH:30]=[CH:31][CH2:32]3)[C:27](=[O:34])[N:26]([CH:35]3[CH2:40][CH2:39][N:38]([CH2:2][C:3]4[CH:12]=[C:11]5[C:6]([CH:7]=[CH:8][C:9](=[O:13])[O:10]5)=[CH:5][CH:4]=4)[CH2:37][CH2:36]3)[N:25]=2)[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]