Hydrochloric Acid → Methyl 3-hydroxy-4,5-dimethoxybenzoate

HRID 967423Notes

Reaction equation

HRID 967423 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([O:13][CH3:14])[C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].Cl.[CH3:16]O>>[CH3:16][O:6][C:5](=[O:7])[C:4]1[CH:8]=[C:9]([O:13][CH3:14])[C:10]([O:11][CH3:12])=[C:2]([OH:1])[CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 747093-Hydroxy-4,5-Dimethoxybenzoic Acid

Product 1

HCID 2733956Methyl 3-hydroxy-4,5-dimethoxybenzoate

Procedure

5 g (27.2 mmol) of 3-Hydroxy-4,5-dimethoxy-benzoic acid was added at 0° C. to 100 ml of a saturated solution of HCl in MeOH. The solution was stirred for 16 h at RT. The solvent was removed under reduced pressure. The residue was chromatographed on silica gel eluting with ethyl acetate/n-heptane (2/1).

Workup

  1. customThe solvent was removed under reduced pressure
  2. customThe residue was chromatographed on silica gel eluting with ethyl acetate/n-heptane (2/1)

Sources & evidence

ORD record
ord-ce05e827eba5407eb510b477ae4de1d5
Source dataset
uspto-grants-2005_10
Patent number
US06953857B2

Reaction notes

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