反应详情

To a solution of 200 mg 3-Isocyanato-benzoic acid methyl ester in 2 ml ethyl acetate is added dropwise a solution of 162 mg 2,4-dichloroaniline in 1 ml ethyl acetate. After 5 h at RT the solvent was removed under reduced pressure and the residue dissolved in 5 ml MeOH/THF/H2O 2:2:1. 100 mg lithium hydroxide monohydrate was added and the mixture stirred over night at RT. After removal of the solvent the residue was acidified by addition of 5 ml half concentrated HCl. The precipitating acid was filtered off and dried.

1. customAfter 5 h at RT the solvent was removed under reduced pressure
2. dissolutionthe residue dissolved in 5 ml MeOH/THF/H2O 2:2:1
3. addition100 mg lithium hydroxide monohydrate was added
4. customAfter removal of the solvent the residue
5. additionwas acidified by addition of 5 ml half concentrated HCl
6. filtrationThe precipitating acid was filtered off
7. customdried