反应详情

温度

0 °C

To a solution of 1 g 1-(4-Chloro-phenyl)-cyclobutanecarboxylic acid in 15 ml THF were added dropwise at 0° C. 9.5 ml BH3*THF in THF (1M). Then the reaction mixture was heated at reflux for 2 h and then cooled again to 0° C. followed by cautious addition of 30 ml methanol. After evaporation of the solvents the residue was codestilled twice with toluene. The crude product was subjected to the subsequent reaction without further purification.

1. temperatureThen the reaction mixture was heated
2. temperatureat reflux for 2 h
3. customAfter evaporation of the solvents the residue
4. customThe crude product was subjected to the subsequent reaction without further purification