Toluene → HCID 178510197, compound

HRID 967465Notes

Reaction equation

HRID 967465 reaction equation
C(OC(=O)[NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([OH:21])[CH:16]=2)[CH2:11][CH2:10]1)(C)(C)C.C1(C)C=CC=CC=1>C(Cl)Cl>[NH2:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][N:18]=[C:17]([OH:21])[CH:16]=2)[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 1140TolueneHCID 178453094HCID 178453094, compound

Product 1

HCID 178510197HCID 178510197, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 500 mg (2′-Hydroxy-3,4,5,6-tetrahydro-2H-[1,4′]bipyridinyl-4-ylmethyl)-carbamic acid tert-butyl ester in 5 ml CH2Cl2 3 ml TFA was added dropwise at 0° C. After 16 h 20 ml toluene were added and the solvent removed under reduced pressure to yield a brown foam.

Workup

  1. customthe solvent removed under reduced pressure
  2. customto yield a brown foam

Sources & evidence

ORD record
ord-bb4ff88136124a5e9d8a4869e5dd8446
Source dataset
uspto-grants-2005_10
Patent number
US06953857B2

Reaction notes

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