反应详情

A mixture of triisopropyl({3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methoxy)silane (intermediate 117, 0.97 g) in tetrahydrofuran (30 ml) was treated with tetraethylammonium fluoride (0.392 g) and the reaction mixture stirred at ambient temperature for 1 hour. The solvent was evaporated and the residue purified by flash column chromatography using cyclohexane:ethyl acetate (2:1) as eluent to give the title compound.

1. customThe solvent was evaporated
2. customthe residue purified by flash column chromatography