Dichloromethane → HCID 86586056, compound

HRID 967617Notes

Reaction equation

HRID 967617 reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH:4]([O:14][CH3:15])[CH2:5][NH:6]C(OC(C)(C)C)=O.C(Cl)[Cl:18]>C(O)(C(F)(F)F)=O>[ClH:18].[CH3:1][O:2][C:3](=[O:16])[C@H:4]([O:14][CH3:15])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 86586057HCID 86586057, compound

Product 1

HCID 86586056HCID 86586056, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

3-tert-Butoxycarbonylamino-2-methoxypropionic acid methyl ester (500 mg. 2 mmol) was dissolved in 10% TFA in DCM (20 mL), and the reaction mixture was stirred at 30 min at ambient temperature. Solvent was removed and the residue co-evaporated twice for 30 mL of 1 N hydrochloric acid in ether. Yield: 320 mg (88%).

Workup

  1. customSolvent was removed

Sources & evidence

ORD record
ord-40a2dbb00da54ce0a9be6a6550c4f984
Source dataset
uspto-grants-2005_10
Patent number
US06953812B2

Reaction notes

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