HCID 86591068, compound → HCID 86591067, compound

HRID 967645Notes

Reaction equation

HRID 967645 reaction equation
C[O:2][C:3](=[O:41])[CH:4]([F:40])[CH2:5][NH:6][C:7](=[O:39])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([NH:27][C:28]([NH:30][C:31]2[CH:36]=[C:35]([Cl:37])[CH:34]=[C:33]([Cl:38])[CH:32]=2)=[O:29])[C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH:22]=3)=[CH:17][CH:16]=2)=[CH:10][CH:9]=1>C1COCC1.CO>[C:21]1([C:18]2[CH:17]=[CH:16][C:15]([CH:14]([NH:27][C:28]([NH:30][C:31]3[CH:32]=[C:33]([Cl:38])[CH:34]=[C:35]([Cl:37])[CH:36]=3)=[O:29])[C:11]3[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH:4]([F:40])[C:3]([OH:41])=[O:2])=[O:39])=[CH:9][CH:10]=3)=[CH:20][CH:19]=2)[CH2:26][CH2:25][CH2:24][CH2:23][CH:22]=1

Participants

4

Reactant 1

HCID 86591068HCID 86591068, compound

Product 1

HCID 86591067HCID 86591067, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

Hydrolysis of (RS)-3-{4-[1-(4-cyclohex-1-enylphenyl)-3-(3,5-dichlorophenyl)ureidomethyl]benzoylamino}-2-fluoropropionic acid methyl ester in a mixture of THF and methanol afforded the title compound.

Sources & evidence

ORD record
ord-64ba8426fcdb49a7b8780bf833c3e062
Source dataset
uspto-grants-2005_10
Patent number
US06953812B2

Reaction notes

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