Lactose monohydrate → (+)-Lactose

HRID 967676Notes

Reaction equation

HRID 967676 reaction equation
O.[OH:2][CH:3]1[O:22][C@H:21]([CH2:23][OH:24])[C@@H:8]([O:9][C@@H:10]2[O:18][C@H:17]([CH2:19][OH:20])[C@H:15]([OH:16])[C@H:13]([OH:14])[C@H:11]2[OH:12])[C@H:6]([OH:7])[C@H:4]1[OH:5]>CC(C)=O>[OH:2][CH:3]1[O:22][C@H:21]([CH2:23][OH:24])[C@@H:8]([O:9][C@@H:10]2[O:18][C@H:17]([CH2:19][OH:20])[C@H:15]([OH:16])[C@H:13]([OH:14])[C@H:11]2[OH:12])[C@H:6]([OH:7])[C@H:4]1[OH:5]

Participants

3

Reactant 1

HCID 62223Lactose monohydrate

Product 1

HCID 440995(+)-Lactose

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Micronised lactose monohydrate (2 g) was placed in a tubular glass screw-cap scintillation vial and acetone (1.2 ml) was applied to the headspace walls to avoid localised overwetting. The vial was capped immediately and rotated by hand at 45° to the vertical to give suitable powder flow to induce balling. An occasional sharp tap on the bench was needed to dislodge powder adhering to the vial or forming large agglomerates. As soon as all free powder had disappeared the pellets were immediately stored over silica gel.

Workup

  1. customThe vial was capped immediately
  2. customrotated by hand at 45°
  3. customto give suitable powder flow
  4. customforming large agglomerates

Sources & evidence

ORD record
ord-56837c00a13b440798631c4d457843c5
Source dataset
uspto-grants-2005_10
Patent number
US06955824B1

Reaction notes

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