Lactose monohydrate → (+)-Lactose

Participants

Reaction Steps

Micronised lactose monohydrate (2 g) was placed in a tubular glass screw-cap scintillation vial and acetone (1.2 ml) was applied to the headspace walls to avoid localised overwetting. The vial was capped immediately and rotated by hand at 45° to the vertical to give suitable powder flow to induce balling. An occasional sharp tap on the bench was needed to dislodge powder adhering to the vial or forming large agglomerates. As soon as all free powder had disappeared the pellets were immediately stored over silica gel.

Provenance & Evidence