HuagongsheHuagongshe Chemistry Print Report · For research reference only
Purine → 4-Amino-2-methyl-5-pyrimidinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Purine | HCID 1044 | — |
| Reactant | Thiamine | HCID 1130 | — |
| Reactant | 5-Aminoimidazole ribonucleotide | HCID 161500 | — |
| Reactant | 5'-Phosphoribosylformylglycinamidine | HCID 5462266 | — |
| Product | 4-Amino-2-methyl-5-pyrimidinemethanol | HCID 777 | — |
Reaction Steps
The following reactions comprise the biosynthesis of thiamine: Thiamine biosynthesis begins with purine metabolism. From here AIR synthetase, the fifth step in the pathway catalyzes the conversion of 5′-phosphoribosyl-N-formylglycinamidine (FGAM) to 5′-phosphoribosyl-5-aminoimidazole (AIR). 4-Amino-5-hydroxymethyl-2-methylpyrimidine is then formed in a series of reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06955890B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-6c6a8c3dc58c44afa8c1cde254ee8d91 |
| Source note | uspto-grants-2005_10 |