Sodium Hydroxide → 4-(4-Carbamoylphenoxymethyl)piperidin-4-ol

HRID 967773Notes

Reaction equation

HRID 967773 reaction equation
[OH-:1].[Na+].C([N:10]1[CH2:15][CH2:14][C:13]([CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=2)([OH:16])[CH2:12][CH2:11]1)C1C=CC=CC=1>C(O)C>[C:25]([C:22]1[CH:23]=[CH:24][C:19]([O:18][CH2:17][C:13]2([OH:16])[CH2:14][CH2:15][NH:10][CH2:11][CH2:12]2)=[CH:20][CH:21]=1)(=[O:1])[NH2:26]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22291260HCID 22291260, compound

Product 1

HCID 222912804-(4-Carbamoylphenoxymethyl)piperidin-4-ol

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4N sodium hydroxide (6.8 mL) was added to an ethanol solution (30 mL) of the compound (2.2 g) obtained in Step 3 of Example 4 and the mixture was heated under reflux for four and half hours. The solvent was removed under reduced pressure and to the residue was added water (30 mL), and the precipitate was collected by filtration.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for four and half hours
  3. customThe solvent was removed under reduced pressure and to the residue
  4. additionwas added water (30 mL)
  5. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-5276b2473bca4975ad5a3bbbfa9eaf93
Source dataset
uspto-grants-2005_10
Patent number
US06956046B2

Reaction notes

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