Sodium Hydroxide → 4-(4-Carbamoylphenoxymethyl)piperidin-4-ol

Participants

Reaction Steps

4N sodium hydroxide (6.8 mL) was added to an ethanol solution (30 mL) of the compound (2.2 g) obtained in Step 3 of Example 4 and the mixture was heated under reflux for four and half hours. The solvent was removed under reduced pressure and to the residue was added water (30 mL), and the precipitate was collected by filtration.

Provenance & Evidence