1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol → 1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride

HRID 967774Notes

Reaction equation

HRID 967774 reaction equation
[ClH:1].CO.[C:4]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)([OH:20])[CH2:16][CH2:15]2)=[CH:8][CH:7]=1)#[N:5]>CO>[ClH:1].[C:4]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][C:17]([CH2:21][O:22][C:23]3[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=3)([OH:20])[CH2:16][CH2:15]2)=[CH:10][CH:11]=1)#[N:5]

Participants

4

Reactant 2

HCID 102916131-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-olHCID 21893726Hydrochloride methanol

Product 1

HCID 222912871-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10% hydrochloric acid-methanol (0.2 mL) was added to a methanol solution (2 mL) of the compound (50 mg) obtained in Step 4 of Example 1. After the solvent was removed under reduced pressure, the residue obtained was crystallized from ether and collected by filtration to obtain the titled compound (48 mg) as crystals.

Workup

  1. customAfter the solvent was removed under reduced pressure
  2. customthe residue obtained
  3. customwas crystallized from ether
  4. filtrationcollected by filtration

Sources & evidence

ORD record
ord-aa80d6da31a1439097d934d520db2c33
Source dataset
uspto-grants-2005_10
Patent number
US06956046B2

Reaction notes

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