HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol → 1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol | HCID 10291613 | — |
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-[2-(4-Cyanophenyl)ethyl]-4-(4-hydroxyphenoxymethyl)piperidin-4-ol hydrochloride | HCID 22291287 | — |
Reaction Steps
10% hydrochloric acid-methanol (0.2 mL) was added to a methanol solution (2 mL) of the compound (50 mg) obtained in Step 4 of Example 1. After the solvent was removed under reduced pressure, the residue obtained was crystallized from ether and collected by filtration to obtain the titled compound (48 mg) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06956046B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-aa80d6da31a1439097d934d520db2c33 |
| Source note | uspto-grants-2005_10 |