Acetic Acid → M-58996

HRID 967786Notes

Reaction equation

HRID 967786 reaction equation
[ClH:1].C(O)(=O)C.[C:6]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][C:19]([CH2:23][N:24]([CH3:34])[C:25]3[CH:33]=[CH:32][C:28]([C:29]([OH:31])=[O:30])=[CH:27][CH:26]=3)([OH:22])[CH2:18][CH2:17]2)=[CH:10][CH:9]=1)#[N:7]>O>[ClH:1].[C:6]([C:8]1[CH:9]=[CH:10][C:11]([CH2:14][CH2:15][N:16]2[CH2:17][CH2:18][C:19]([CH2:23][N:24]([CH3:34])[C:25]3[CH:26]=[CH:27][C:28]([C:29]([OH:31])=[O:30])=[CH:32][CH:33]=3)([OH:22])[CH2:20][CH2:21]2)=[CH:12][CH:13]=1)#[N:7]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 12986481UP9V9DB2RD

Product 1

HCID 67371796M-58996

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2N hydrochloric acid (76 μL) was added to an acetic acid solution (100 μL) of the compound (50.0 mg) obtained in Example 14 to prepare homogenous solution. Water (400 μL) was gradually added under stirring and left at rest at room temperature for thirty minutes. The precipitate was collected by filtration and washed with water, ethyl acetate and ether successively, and dried to obtain the titled compound (48.2 mg) as crystals.

Workup

  1. customto prepare homogenous solution
  2. waitleft at rest at room temperature for thirty minutes
  3. filtrationThe precipitate was collected by filtration
  4. washwashed with water, ethyl acetate and ether successively
  5. customdried

Sources & evidence

ORD record
ord-768c35ea778644908f8b4f72e73d4fbe
Source dataset
uspto-grants-2005_10
Patent number
US06956046B2

Reaction notes

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