Triethylamine → HCID 178516267, compound

HRID 967800Notes

Reaction equation

HRID 967800 reaction equation
CCN(CC)CC.C(O[C:16](=[O:32])[CH2:17][C:18](=O)[CH2:19][O:20][C:21]12[CH2:30][CH:25]3[CH2:26][CH:27]([CH2:29][CH:23]([CH2:24]3)[CH2:22]1)[CH2:28]2)C1C=CC=CC=1.Cl.[CH:34]1([NH:40][NH2:41])[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>CCO>[C:21]12([O:20][CH2:19][C:18]3[CH:17]=[C:16]([OH:32])[N:40]([CH:34]4[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]4)[N:41]=3)[CH2:28][CH:27]3[CH2:29][CH:23]([CH2:24][CH:25]([CH2:26]3)[CH2:30]1)[CH2:22]2

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 207836Cyclohexylhydrazine hydrochlorideHCID 697440854-(Adamantan-1-yloxy)-3-oxo-butyric acid benzyl ester

Product 1

HCID 178516267HCID 178516267, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

NEt3 (800 μl, 5.7 mmol) was added to a solution of 4-(adamantan-1-yloxy)-3-oxo-butyric acid benzyl ester (1.91 g, 5.6 mmol), and cyclohexyl hydrazine hydrochloride (877 mg, 5.82 mmol) in EtOH (30 mL) at 0° C. The mixture was allowed to warm to room temperature and stirred for 4 h. The precipitated white solid was filtered and dried to afford the product as a white solid, (1.23 g, 66%.).

Workup

  1. filtrationThe precipitated white solid was filtered
  2. customdried

Sources & evidence

ORD record
ord-d336fa6eec8340a488e9f4adf019c0b4
Source dataset
uspto-grants-2005_10
Patent number
US06956053B2

Reaction notes

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