2-Chlorobenzenesulfonamide → HCID 22291403, compound

HRID 967838Notes

Reaction equation

[C:1]1([C:7]2[N:8]=[C:9]([C:30]([F:33])([F:32])[F:31])[N:10]([C:12]3[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][NH:20][C:21](=O)[O:22]C4C=CC=CC=4)=[CH:14][CH:13]=3)[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[S:41]([NH2:44])(=[O:43])=[O:42]>>[Cl:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[S:41]([NH:44][C:21]([NH:20][CH2:19][CH2:18][C:15]1[CH:14]=[CH:13][C:12]([N:10]2[CH:11]=[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[N:8]=[C:9]2[C:30]([F:31])([F:32])[F:33])=[CH:17][CH:16]=1)=[O:22])(=[O:43])=[O:42]

Participants

Reactant 2

HCID 814102-Chlorobenzenesulfonamide

HCID 22291394HCID 22291394, compound

Product 1

HCID 22291403HCID 22291403, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-{4-[4-phenyl-2-(trifluoromethyl)-1H-imidazol-1-yl]phenyl}ethylcarbamate and 2-chlorobenzenesulfonamide. MS (ESI) m/z 549 [M+H]+, 547 [M−H]−, 1H-NMR (CDCl3) δ 2.86 (2H, t, J=7.3 Hz), 3.48-3.55 (2H, m), 6.58 (1H, br), 7.25-7.28 (1H, m), 7.31-7.36 (3H, m), 7.25-7.28 (1H, m), 7.39-7.47 (4H, m), 7.58-7.61 (2H, m), 7.82 (2H, dd, J=8.4, 1.4 Hz), 8.00 (2H, d, J=7.5 Hz).

Sources & evidence

ORD record: ord-860945c850f2466a8b7d4dabde6f62cc
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06956050B2

Reaction notes

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