反应详情

The title compound was prepared by reacting 4-(1-ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenoxy)-pyridine-3-carbaldehyde with methylithium lithium in THF at −78° C. The desired product was isolated after silica gel column chromatography to give 60.1% of colorless oil. 1H NMR(CDCl3) d 6.87(s, 2H), 6.06(s, 1H), 5.7(q, 1H), 3.3(m, 1H), 2.29(s, 3H), 2.12(s, 6H), 2.069s, 3H), 1.4-1.7(m, 4H), 1.59(d, 3H), 0.8-1.0(m, 6H) ppm.

1. customThe title compound was prepared
2. customat −78° C