Sodium borohydride → HCID 69587603, compound

HRID 967996Notes

Reaction equation

HRID 967996 reaction equation
[CH2:1]([CH:3]([NH:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([O:14][C:15]2[C:22]([CH3:23])=[CH:21][C:18]([CH:19]=[O:20])=[CH:17][C:16]=2[CH3:24])[C:8]=1[CH3:25])[CH2:4][CH3:5])[CH3:2].[BH4-].[Na+]>CO>[CH2:1]([CH:3]([NH:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([O:14][C:15]2[C:16]([CH3:24])=[CH:17][C:18]([CH2:19][OH:20])=[CH:21][C:22]=2[CH3:23])[C:8]=1[CH3:25])[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 86584324HCID 86584324, compound

Product 1

HCID 69587603HCID 69587603, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4-[4-(1-Ethyl-propylamino)-3,6-dimethyl-pyridin-2-yloxy]-3,5-dimethyl-benzaldehyde and sodium borohydride in methanol was stirred at room temperature. After standard work-up procedure and purification, the title compound was obtained as a solid. 1H NMR(CDCl3) d 7.06(s, 2H), 6.08(s, 1H), 4.64(s, 2H), 3.74(d, 1H), 3.33(m, 1H), 2.14(s, 3H), 2.13(s, 3H), 2.11(s, 6H) ppm.

Workup

  1. customAfter standard work-up procedure and purification

Sources & evidence

ORD record
ord-b1beaddef4904cb3b635962a1827fd08
Source dataset
uspto-grants-2005_10
Patent number
US06956047B1

Reaction notes

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