反应详情

A solution of nervonoyl chloride (26 mmol, 10.0 g) in dichloromethane (50 mL) was added drop-wise to a cooled solution (0° C.) of N-hydroxysuccinimide (26 mmol, 3.0 g) and triethylamine (52 mmol, 5.2 g) in dicholoromethane (200 mL). The reaction was stirred for one hour after the addition was complete. TLC analysis (80:18:2 hexane-diethyl ether-acetic acid) indicated complete reaction. The reaction mixture was poured into hexane, filtered and concentrated to dryness. Recrystallisation from ethanol yielded succinimidyl nervonate as a white solid.

1. additionafter the addition
2. customreaction
3. filtrationfiltered
4. concentrationconcentrated to dryness
5. customRecrystallisation from ethanol