HRID968092

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID107468

Lysine ethyl ester dihydrochloride

C8H20Cl2N2O2

$结构：CCCCCCCC/C=C\CCCCCCCCCCCCCC(=O)ON1C(=O)CCC1=O$

HCID45040426

未命名化合物

PRODUCTS

生成物

$结构：CCCCCCCC/C=C\CCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCC/C=C\CCCCCCCC)C(=O)OCC$

HCID9854221

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

To a stirred suspension of L-lysine ethyl ester dihydrochloride (6 mmol, 1.4 g, commercially available) and triethylamine (36 mmol, 3.6 g) in chloroform (80 mL), succinimidyl nervonate (18 mmol, 8.4 g, prepared as described in Example 1) was added in portions at room temperature. Stirring was continued overnight and, after removal of the solvent under reduced pressure, the product was crystallised from ethanol:water (1:1), yielding the title compound.

WORKUP

后处理

customafter removal of the solvent under reduced pressure
customthe product was crystallised from ethanol:water (1:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dd60471e9ad647ccab9548a15c615ad3
来源数据集: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06956059B2
来源说明: uspto-grants-2005_10

反应 SMILES

Cl.Cl.[CH2:3]([O:5][C:6](=[O:14])[C@H:7]([CH2:9][CH2:10][CH2:11][CH2:12][NH2:13])[NH2:8])[CH3:4].C(N([CH2:20][CH3:21])CC)C.[C:22]([O:47]N1C(=O)CCC1=O)(=O)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]/[CH:36]=[CH:37]\[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45]>C(Cl)(Cl)Cl>[CH2:3]([O:5][C:6](=[O:14])[C@H:7]([CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:22](=[O:47])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]/[CH:36]=[CH:37]\[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:20][CH3:21])[NH:8][C:22](=[O:47])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]/[CH:36]=[CH:37]\[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH3:45])[CH3:4]